Stem cells provide two major benefits for cell therapy. First, they provide a cell type that can self-renew and may survive the lifetime of the patient. Second, stem cells provide daughter cells that mature into the specialized cells of each tissue. These differentiated daughter cells can replace the diseased cells of the afflicted tissue(s). Therefore, cell therapy that uses stem cells theoretically improves the disease condition for as long as those modified stem cells live, potentially the lifetime of the patient.
Lovinium-iPSC Differentiated Cells are fully characterized progenitors and differentiated cell lines derived from integration-free iPSCs using feeder-free culture protocols. The cells have been characterized for the expression of characteristic biomarkers using immunohistochemistry, as well as for functional viability. These cells are ideal for various applications in biomedical and applied research, including disease modeling, drug target discovery, neurotoxicity and cardiotoxicity drug screening, drug efficacy testing for new neurological drug candidates, and cell-based therapeutic research.
Induced Pluripotent Stem Cell-derived cardiomyocytes
Heart failure is a life-threatening disorder worldwide, and is treated by drug therapies and surgical interventions. However, these treatments can lack effectiveness in the long term and are associated with infection and donor shortage. Significant advances have been made in the field of cardiac diseases and stem cell transplantation-based therapies have emerged as promising therapeutic tools for improving cardiac regeneration and function. Induced Pluripotent Stem Cell-derived cardiomyocytes have paracrine effects, they also have the potential to supply newly born myocytes that can function synchronously with the recipient myocardium as “mechanically working cells” in severely damaged myocardium.
In contrast to other cell types, iPSCs can differentiate into functional cardiomyocyte cells through spontaneous differentiation or directed differentiation strategies. Directed differentiation strategies require multiple steps of directed differentiation to obtain functional cardiomyocytes from iPSCs.
Induced Pluripotent Stem Cell-derived Neurocyte
Our iPSC-derived neurocyte service is a unique way to generate clinically relevant, patient- and disease-specific neural models for drug discovery and development.
The process of iPSC differentiation to neurons and neuronal cells is of special importance for neurobiology and related disorders, considering the dearth of clinically relevant in vitro models available for research, drug screening, and development, as well as the lack of therapy to reverse neuronal damage.
Our iPSC-derived neurocytes can be used to investigate neurological diseases such as Alzheimer’s disease (AD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), epilepsy, stroke and brain injury or trauma.